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Characteristic
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CVID (n = 114)
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IgGSD (n = 126)
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|---|
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Men: Women
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32: 82
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38: 88
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Age at Diagnosis, y (range)
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54 ± 16 (21 – 87)
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51 ± 13 (18 – 89)
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Serum Total IgG, mg/dL (range)
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527 ± 115 (140 – 697)
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953 ± 199 (700 – 1751)
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Deficient IgG Subclass(es)
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Percentage (n)
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Percentage (n)
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1, 3
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38.6 (44)
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8.7 (11)
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1
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16.7 (19)
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17.5 (22)
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1, 2, 3
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12.3 (14)
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0
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3
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7.0 (8)
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52.4 (66)
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1, 2
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7.0 (8)
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0
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1, 3, 4
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7.0 (8)
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0
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1, 4
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5.3 (6)
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3.2 (4)
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2, 3
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3.5 (4)
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1.6 (2)
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1, 2, 3, 4
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2.6 (3)
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0
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2
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0.9 (1)
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3.2 (4)
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1, 2, 4
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0.9 (1)
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0
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4
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0
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7.9 (10)
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3, 4
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0
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4.8 (6)
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2, 3, 4
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0
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0.8 (1)
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Index Patients with Serum IgA Deficiency, % (n)
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21.1 (24)
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9.5 (12)
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Index Patients with Serum IgM Deficiency, % (n)
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18.4 (21)
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7.9 (10)
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1 By definition, all probands with CVID had subnormal serum concentrations of total IgG at diagnosis; mean serum IgG concentrations were significantly lower in CVID (p < 0.000.1; two-tail t-test). The percentage of index patients with IgA deficiency was significantly greater in CVID (p = 0.0293; Chi-square test). The percentage of index patients with IgM deficiency was significantly greater in CVID (p = 0.0156; Chi-square test).
