Unannotated single nucleotide polymorphisms in the TATA box of erythropoiesis genes show in vitro positive involvements in cognitive and mental disorders

Table 1 Predictions of the influence of SNPs in the promoters of the hemoglobin subunit genes on TBP–TATA affinity, as performed by SNP-TATA-Z-tester [31]

Gene	Alleles, WT or mut	DNA sequence, TATA-like box; 5′-3′	Prognosis, −ln K_D
HBB	WT rs63750400:G rs281864525:T rs34598529:G rs33980857:A rs33980857:C rs33980857:G rs33981098:C rs33981098:A rs34500389:T rs34500389:A rs33931746:C	cagggctgggcataaaactcagggcagag cagggctgggcataaaaGtcagggcagag cagggctgggcataaaTctcagggcagag cagggctgggcatGaaactcagggcagag cagggctgggcaAaaaactcagggcagag cagggctgggcaCaaaactcagggcagag cagggctgggcaGaaaactcagggcagag cagggctgggcCtaaaactcagggcagag cagggctgggcGtaaaattcagggcagag cagggctgggTataaaactcagggcagag cagggctgggActaaaactcagggcagag cagggctgggcataCaactcagggcagag	19.20 19.12 19.169 17.849 17.701 18.172 17.673 18.553 18.062 20.175 18.635 18.341
HBB_2	WT rs35518301:G	ggaccagcacaaaaggcagggcagag ggaccagcacGaaaggcagggcagag	19.29 18.65
HBZ	WT rs113180943:T rs1035033590:C	cagctccctgtaataaggggaccctg cagctccctgtaTtaaggggaccctg cagctccctgtaataaggCgaccctg	20,76 19,28 20,773
HBZ_3	WT rs559282746:G	ggagggtggggcccctatctctcct ggagggtggggcGcctatctctcct	17.611 17.605
HBA1	WT rs571582665:T	gcgccccaagcataaacctggcgcgc gcgccccaagcataaacTtggcgcgc	18.36 18.62
HBG1	WT rs573241527:G	agggtgcttccttttattcttcatcc agggtgcttccttttCttcttcatcc	19.06 17.54
HBM	WT rs905730148:A rs937192507:C	ggtgcccggaggctctataaggaggc ggtgcccggagAccctataaggaggc ggtgcccggaggcccCataaggaggc	19.13 19.23 19.95
HBE1	WT rs768296486:A rs1036491581:G rs150246840:C	aggcaaaaagagagcttgtgtagagc aggcaaaaagagagAttgtgtagagc aggcaaaaagagagaGtgtgtagagc aggcaaaaagagaggttgtgtagCgc	18.31 18.16 18.01 18.16

Notes: Ancestral (WT) and minor (mut) alleles; K_D, dissociation constant of the TBP–DNA complex [13]; Genes: HBB, β-globin; HBB_2, β-globin promoter 2; HBZ zeta-globin; HBZ_3 zeta-globin promoter 3; HBA1, α1-globin; HBG1 Aγ globin; HBM Hemoglobin subunit μ; and HBE1 ε-globin

ISSN: 1471-2350