Glutathione S-transferase M1 and T1 genes deletion polymorphisms and risk of developing essential hypertension: a case-control study in Burkina Faso population (West Africa)

Table 4 BMI, age, and sex stratified analysis of association between GSTM1 and GSTT1 variants with essential hypertension

Genes	Parameters	groups	Variants (n)		OR	CI (95%)	p value
Genes	Parameters	groups		active	OR	CI (95%)	p value
GSTM1	BMI < 30 Kg/m²	Cases	38	124	–
	BMI < 30 Kg/m²	Controls	72	167	0.71	0.45–1.12	0.17
	BMI ≥ 30 Kg/m²	Cases	24	59	–
	BMI ≥ 30 Kg/m²	Controls	12	18	0.61	0.25–1.45	0.36
GSTT1	BMI < 30 Kg/m²	Cases	113	49	–
	BMI < 30 Kg/m²	Controls	135	104	1.77	1.16–2.70	0.008*
	BMI ≥ 30 Kg/m²	Cases	57	26	–
	BMI ≥ 30 Kg/m²	Controls	15	15	2.19	0.93–5.14	0.07
GSTM1	Smoking YES	Cases	15	50	–
	Smoking YES	Controls	13	48	1.10	0.47–2.57	0.83
	Smoking NO	Cases	47	133	–
	Smoking NO	Controls	71	137	0.68	0.43–1.05	0.09
GSTT1	Smoking YES	Cases	46	19	–
	Smoking YES	Controls	37	24	1.57	0.74–3.29	0.26
	Smoking NO	Cases	124	56	–
	Smoking NO	Controls	113	95	1.86	1.22–2.82	0.003*
GSTM1	Alcohol intake YES	Cases	26	92	–
	Alcohol intake YES	Controls	27	52	0.47	0.25–0.88	0.07
	Alcohol intake NO	Cases	36	91	–
	Alcohol intake NO	Controls	57	133	0.99	0.60–1.63	0.80
GSTT1	Alcohol intake YES	Cases	86	32	–
	Alcohol intake YES	Controls	45	38	2.26	1.25–4.10	0.007*
	Alcohol intake NO	Cases	84	43	–
	Alcohol intake NO	Controls	105	81	1.50	0.94–2.40	0.09

Analysis by chi-square to obtain odds ratio values (OR) and confidence interval; CI Confidence interval, OR Odds ratio; *: significant difference between groups (p < 0.05)

ISSN: 1471-2350